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Consulting and training
for your clinical development

Publications

1 - Population PKPD modelling of soluble biomarkers ANP and BigET1 for 2 endopeptidase inhibitors   PAGE2007 Copenhaguen  M. Marchand, E. Fuseau, A.C. Heatherington, S. Sultana, P. R. Hidi, M. Boucher, P. Ellis, S.W. Martin

2 - Predicting human PK from animal PBPK simulation combined with in vitro data   PAGE2007 Copenhaguen  M. Marchand, E. Fuseau

3 - Supporting the recommended paediatric dosing regimen for rufinamide using clinical trial simulation   PAGE2007 Copenhaguen  Mathilde Marchand, Eliane Fuseau, David Critchley

4 - Elimination of anti-epileptic compounds in Marseille aquatic environment from private hospital effluent - modelling versus measurements    PAGE2007 Copenhaguen  C.Crepin, E.Fuseau, M.Portugal, D.Humiler

5 - Selection of a dosing regimen with WST11 by Monte Carlo simulations, using PK data collected after single IV administration in healthy subjects and population PK modelling   PAGE2007 Copenhaguen  M.A. Fabre, E. Fuseau, Ficheux.

6 - Population pharmacokinetic analysis in children, adolescents and adults with schizophrenia or bipolar disorder   PAGE2007 Copenhaguen  M.A. Fabre, E. Fuseau, A. Vermeulen, A. Thyssen.

7 - Pooled PK analysis of a new CNS drug, in healthy subjects.    PAGE2007 Copenhaguen  M. Vernaz-Gris, E. Fuseau, L. Del Frari, V. Brunner, P. Hermann

8 - Retrospective population pharmacokinetic analysis of seletracetam in epileptic and healthy adults   PAGE2007 Copenhaguen  N. Toublanc, MA Fabre, E Fuseau

9 - Extrapolation from preclinical PKPD data to clinical response, Application to a new antiepileptic medication  Measurements and Kinetics of in vivo Drug Effects.  26-29 April 2006 Noordwijkerhout (The Netherlands).   Marchand M, Petricoul O, Fuseau E, Bentley D, Critchley D.

10 - Extrapolation from preclinical PKPD data to clinical response, Application to a new antiepileptic medication  PAGE 2006 Bruges  Marchand M, Petricoul O, Fuseau E, Bentley D, Critchley D.

11 - Photochemical Patterning of Biological Molecules Inside a Glass Capillary.    Anal. Chem. 2005 Sep 1; 77(17) pp 5474 – 5479.   Balakirev MY, Porte S, Vernaz-Gris M, Berger M, Arie JP, Fouque B, Chatelain F.

12 - Describing the Exposure-response relationship of Rufinamide in Patients with Epilepsy  AES Annual Meeting, December 2005, Washington DC (USA).    Fuseau E, Brodie M, Petricoul O, Cr诩n C, Arroyo S, Critchley D.

13 - Population pharmacokinetics of onercept in healthy subjects.    Clin Pharmacokinet. 2005;44(12):1295-304.   Glatt S, Fuseau E, Buraglio M, Nguyen QT.

14 - Understanding the variability in clinical response to rufinamide, a new antiepileptic drug: a pooled PKPD analysis  PAGE2005 Pamplona (Spain).   Petricoul O, Cosson V, Cr诩n C, E. Fuseau, Critchley D.

15 - Pharmacokinetics of sumatriptan nasal spray in children.    J Clin Pharmacol. 2004 Apr;44(4):359-67.   Christensen ML, Mottern RK, Jabbour JT, Fuseau E.

16 - Pharmacokinetic modeling of valproic acid from routine clinical data in Egyptian epileptic patients.  Eur J Clin Pharmacol. 2004 Jan;59(11):783-90. Epub 2003 Dec 12.   EL Desoky ES, Fuseau E, EL Din Amry S, Cosson V.

17 - Pharmacokinetics of sumatriptan nasal spray in adolescents.    J Clin Pharmacol. 2003 Jul;43(7):721-6.    Christensen ML, Mottern RK, Jabbour JT, Fuseau E.

18 - Information indexes for exploratory data analysis in population pharmacokinetics   PAGE2002, Paris (France)  Baille-Albert P, Petricoul O, Fuseau E, Iliadis A.

19 - Clinical pharmacokinetics of intranasal sumatriptan.    Clin Pharmacokinet. 2002;41(11):801-11. Review.   Fuseau E, Petricoul O, Moore KH, Barrow A, Ibbotson T.

20 - CNS effects of sumatriptan and rizatriptan in healthy female volunteers.    Cephalalgia. 2002 May;22(4):271-81.   van der Post J, Schram MT, Schoemaker RC, Pieters MS, Fuseau E, Pereira A, Baggen S, Cohen AF, van Gerven JM.

21 - Pharmacokinetics of naratriptan in adolescent subjects with a history of migraine.    J Clin Pharmacol. 2001 Feb;41(2):170-5.    Christensen ML, Eades SK, Fuseau E, Kempsford RD, Phelps SJ, Hak LJ.

22 - Effect of encapsulation on absorption of sumatriptan tablets: data from healthy volunteers and patients during a migraine.    Clin Ther. 2001 Feb;23(2):242-51.   Fuseau E, Petricoul O, Sabin A, Pereira A, O'Quinn S, Thein S, Leibowitz M, Purdon H, McNeal S, Salonen R, Metz A, Coates P.

23 - Modeling and stimulation for clinical trial design involving a categorical response: a phase II case study with naratriptan.    Pharm Res. 2001 Aug;18(8):1210-9.   Nestorov I, Graham G, Duffull S, Aarons L, Fuseau E, Coates P.

24 - Population Pharmacokinetic/ Pharmacodynamic modeling of Antide in patients undergoing stimulation of multiple follicular development for assisted reproductive technology with recombinant human Follicle Stimulating Hormone  PAGE2001, Basel (Switzerland).   Petricoul O, T. X. Nguyen Q, Decosterd G, Loumaye E, Munafo

25 - Population Pharmacokinetic/Pharmacodynamic modeling of Ovidrel in HIV-related male hypogonadotropic hypogonadism  PAGE2001, Basel (Switzerland).   T. X. Nguyen Q, Petricoul O, Cerutti B, Maislich L, Saunders H, Loumaye E, Munafo A.

26 - Mixed effect modeling of sumatriptan pharmacokinetics during drug development: II. From healthy subjects to phase 2 dose ranging in patients.  J Pharmacokinet Biopharm. 1999 Apr;27(2):149-71.   Cosson VF, Fuseau E.

27 - A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses: the antiemetic effect of ondansetron.   J Pharmacokinet Biopharm. 1999 Dec;27(6):625-44.   Cox EH, Veyrat-Follet C, Beal SL, Fuseau E, Kenkare S, Sheiner LB.

28 - Meta-analysis of the exposure/efficacy relationship for sumatriptan nasal spray  ASCPT1999, San Antonio (Texas, USA)).    Petricoul O, Fuseau E.

29 - Early clinical experience with subcutaneous naratriptan in the acute treatment of migraine: a dose-ranging study.    Eur J Neurol. 1998 Sep;5(5):469-477.   Dahlof C, Hogenhuis L, Olesen J, Petit H, Ribbat J, Schoenen J, Boswell D, Fuseau E, Hassani H, Winter P.

30 - Comparative clinical pharmacokinetics of single doses of sumatriptan following subcutaneous, oral, rectal and intranasal administration.    Eur J Pharm Sci. 1998 Apr;6(2):99-104.   Duquesnoy C, Mamet JP, Sumner D, Fuseau E.

31 - Mixed effect modeling of sumatriptan pharmacokinetics during drug development. I: Interspecies allometric scaling.    J Pharmacokinet Biopharm. 1997 Apr;25(2):149-67.   Cosson VF, Fuseau E, Efthymiopoulos C, Bye A.

32 - Safety, tolerability, and pharmacokinetics of sumatriptan in healthy subjects following ascending single intranasal doses and multiple intranasal doses.    Cephalalgia. 1997 Jun;17(4):541-50.   Moore KH, Hussey EK, Shaw S, Fuseau E, Duquesnoy C, Pakes GE.

33 - Plasma and skin suction-blister-fluid pharmacokinetics and time course of the effects of oral mizolastine.    Eur J Clin Pharmacol. 1996;50(4):327-33.   Chosidow O, Dubruc C, Danjou P, Fuseau E, Espagne E, Bianchetti G, Thenot JP, Herson S, Rosenzweig P, Revuz J.

34 - Reduction of hyperglycemia after oral glucose load by the new alpha 2-adrenergic receptor antagonist SL 84.0418 in healthy subjects.    Clin Pharmacol Ther. 1994 Mar;55(3):338-45.   Berlin I, Rosenzweig P, Chalon S, Fuseau E, Landault C, Cesselin F, Blacker C, Puech AJ.

35 - Effects of zolpidem versus diazepam and placebo on breathing control parameters in healthy human subjects.    Int J Clin Pharmacol Res. 1992;12(1):27-35.   Maillard D, Thiercelin JF, Fuseau E, Rosenzweig P, Attali P.

36 - Pharmacodynamics and pharmacokinetics of mizolastine (SL 85.0324), a new nonsedative H1 antihistamine.    Ann Allergy. 1992 Aug;69(2):135-9.   Rosenzweig P, Thebault JJ, Caplain H, Dubruc C, Bianchetti G, Fuseau E, Morselli PL.

37 - Nocturnal profile of growth hormone secretion during sleep induced by zolpidem: a double-blind study in young adults and children.    Horm Res. 1991;35(1):30-4.   Colle M, Rosenzweig P, Bianchetti G, Fuseau E, Ruffie A, Ruedas E, Morselli PL.

38 - Combined low-dose acetylsalicylic acid and dihydroergotamine in migraine prophylaxis. A double-blind, placebo-controlled crossover study.    Cephalalgia. 1988 Sep;8(3):187-92.   Bousser MG, Chick J, Fuseau E, Soisson T, Thevenet R.

39 - Simultaneous modeling of pharmacokinetics and pharmacodynamics with a nonparametric pharmacodynamic model.    Clin Pharmacol Ther. 1984 Jun;35(6):733-41.   Fuseau E, Sheiner LB.

40 - Pharmacokinetic and clinical investigation of amoxicillin administered intravenously in the newborn    Pathol Biol (Paris). 1982 Jun;30(6 Pt 2):476-80. French.   Peskine F, Despaux E, Rodiere M, Balmayer B, Kassis J, Fuseau E, Brunel D.